![]() Studies, 7 others (16%) had found effects that were stronger than those of Of these, 7 (16%) were contradicted by subsequent Results Of 49 highly cited original clinical research studies, 45 claimed that The same analysis was also performed comparatively for matched studies Studies of comparable or larger sample size and similar or better controlledĭesigns. Main Outcome Measure The results of highly cited articles were compared against subsequent Whether specific characteristics are associated with such refutation overĭesign All original clinical research studies published in 3 major generalĬlinical journals or high-impact-factor specialty journals in 1990-2003 andĬited more than 1000 times in the literature were examined. Objectives To understand how frequently highly cited studies are contradicted orįind effects that are stronger than in other similar studies and to discern ControversiesĪre most prominent when high-impact research is involved. On the effectiveness of interventions are subsequently contradicted. ![]() Shared Decision Making and CommunicationĬontext Controversy and uncertainty ensue when the results of clinical research.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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